翻訳と辞書 Words near each other ・ Thymidine kinase ・ Thymidine kinase 1 ・ Thymidine kinase from herpesvirus ・ Thymidine monophosphate ・ Thymidine phosphorylase ・ Thymidine triphosphate ・ Thymidine-triphosphatase ・ Thymidylate 5'-phosphatase ・ Thymidylate kinase ・ Thymidylate synthase ・ Thymidylate synthase (FAD) ・ Thymidylate synthase inhibitor ・ Thymine ・ Thymine dioxygenase ・ Thymine glycol ・ Thymine-DNA glycosylase ・ Thymineless death ・ Thymio ・ Thymioptila ・ Thymios Karakatsanis ・ Thymios Vlachavas ・ Thymistadopsis ・ Thymistadopsis albidescens ・ Thymistadopsis trilinearia ・ Thymistadopsis undulifera ・ Thymistida ・ Thymistida nigritincta ・ Thymistida tripunctata ・ Thymistida undilineata ・ Thymme Jones Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Thymine-DNA glycosylase ： ウィキペディア英語版 Thymine-DNA glycosylase G/T mismatch-specific thymine DNA glycosylase is an enzyme that in humans is encoded by the TDG gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6996 )〕 Several bacterial proteins have strong sequence homology with this protein. == Function == The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12.〔 Additionally, in 2011, the human thymine DNA glycosylase (hTDG) was reported to efficiently excises 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC), the key oxidation products of 5-methylcytosine in genomic DNA. Later on, the crystal structure of the hTDG catalytic domain in complex with duplex DNA containing 5caC was published, which supports the role of TDG in mammalian 5-methylcytosine demethylation. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Thymine-DNA glycosylase」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.